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رحمتی, مسعود, مهرابی فرد, حدیث. (1402). نقش هسته‌های عضلانی در حافظه و سازگاری‌های عضلانی. , 15(59), 59-80. doi: 10.22089/spj.2024.14534.2240
مسعود رحمتی; حدیث مهرابی فرد. "نقش هسته‌های عضلانی در حافظه و سازگاری‌های عضلانی". , 15, 59, 1402, 59-80. doi: 10.22089/spj.2024.14534.2240
رحمتی, مسعود, مهرابی فرد, حدیث. (1402). 'نقش هسته‌های عضلانی در حافظه و سازگاری‌های عضلانی', , 15(59), pp. 59-80. doi: 10.22089/spj.2024.14534.2240
رحمتی, مسعود, مهرابی فرد, حدیث. نقش هسته‌های عضلانی در حافظه و سازگاری‌های عضلانی. , 1402; 15(59): 59-80. doi: 10.22089/spj.2024.14534.2240

نقش هسته‌های عضلانی در حافظه و سازگاری‌های عضلانی

فیزیولوژی ورزشی
دوره 15، شماره 59، مهر 1402، صفحه 59-80    اصل مقاله (875.07 K)
نوع مقاله: مقاله مروری
شناسه دیجیتال (DOI): 10.22089/spj.2024.14534.2240
نویسندگان
مسعود رحمتی* 1؛ حدیث مهرابی فرد2
1استاد فیزیولوژی ورزش، دانشکده ادبیات و علوم انسانی، دانشگاه لرستان، لرستان، ایران.
2دانشجوی کارشناسی ارشد فیزیولوژی ورزش، دانشکده ادبیات و علوم انسانی، دانشگاه لرستان، لرستان، ایران
چکیده
اهداف: عضله اسکلتی شکل‌‌پذیری بسیار بالایی جهت سازگاری با محرک‌هایی نظیر فعالیت انقباضی، شرایط بارگذاری (بی باری، بی تحرکی، بیماری و فضانوردی)، مداخلات تغذیه‌ای و عوامل محیطی دارد. عضله اسکلتی قابلیت منحصربه فردی دارد که به آن این امکان را می‌دهد که فعالیت انقباضی مزمن قبلی خود را به خاطر بیاورد و در پاسخ به دوره تمرینی مجدد، حتی بعد از یک دوره طولانی مدت بی‌تمرینی، رشد و سازگاری سریع‌تری را از خود نشان دهد. دانشمندان این پدیده را حافظه عضلانی نامیده اند. مطالعات اولیه این پدیده را به یادگیری حرکتی از طریق سیستم عصبی مرکزی نسبت دادند، اما مطالعات بعدی پیشنهاد کردند که حافظه عضلانی ممکن است با محتوای هسته‌های عضله اسکلتی ارتباط داشته باشد. یکی از سازوکارهای احتمالی این است که دوره اولیه تمرین ورزشی منجر به افزایش هسته‌های عضلانی می شود و این هسته‌ها حتی به دنبال یک دوره طولانی مدت بی‌تمرینی در عضله اسکلتی پایدار باقی می‌مانند. به دنبال دوره تمرین مجدد، عضله‌ای که هسته‌های آن در دوره تمرینی اولیه افزایش یافته‌اند، می‌تواند رشد کارآمدتری داشته باشد و پاسخ شکل پذیری سریع‌تری را از خود نشان دهد. اما، مطالعات بعدی نشان دادند که هسته‌های عضلانی ممکن است پایدار نباشند و به‌دنبال دوره‌های بی‌تمرینی از بین بروند. مطالعات اخیر به بررسی سازوکارهای دیگری نظیر اپی ژنتیک در توجیه نظریه حافظه عضلانی پرداختند. به طور کلی، شواهد موجود از ثبات هسته‌های عضلانی در نظریه حافظه عضلانی حمایت نمی‌کند و پیشنهاد می‌شود که شواهد دیگری نظیر اپی ژنتیک در راستای توجیه این نظریه توسط محققین مورد بررسی قرار بگیرد.
کلیدواژه‌ها
عضله اسکلتی؛ هسته عضلانی؛ حافظه عضلانی
مراجع
  1. Koch SC, Müller C, Summa M, Fuchs T. Body memory, metaphor and movement. Body Memory, Metaphor and Movement. 2012:1-476.
  2. Smith S. Body Memories: And Other Pseudo-Scientific Notions of «Survivor Psychology». Issues in Child Abuse Accusations. 1993;5(4):220-34.
  3. Mackay CR. Dual personality of memory T cells. Nature. 1999;402(6763):3-4.
  4. Alvarez RM, Margulies KB. Epigenetic memory and cardiac cell therapy. American College of Cardiology Foundation Washington, DC; 2014. p. 449-50.
  5. Li E, Zhang Y. DNA methylation in mammals. Cold Spring Harbor Perspectives in Biology. 2014;6(5):a019133.
  6. Chang HY, Chi J-T, Dudoit S, Bondre C, van de Rijn M, Botstein D, et al. Diversity, topographic differentiation, and positional memory in human fibroblasts. Proceedings of the National Academy of Sciences. 2002;99(20):12877-82.
  7. Diedrichsen J, Kornysheva K. Motor skill learning between selection and execution. Trends in Cognitive Sciences. 2015;19(4):227-33.
  8. Staron RS, Leonardi MJ, Karapondo DL, Malicky ES, Falkel JE, Hagerman FC, et al. Strength and skeletal muscle adaptations in heavy-resistance-trained women after detraining and retraining. Journal of Applied Physiology. 1991;70(2):631-40.
  9. Taaffe D, Marcus R. Dynamic muscle strength alterations to detraining and retraining in elderly men. Clinical Physiology. 1997;17(3):311-24.
  10. Rutherford O, Jones D. The role of learning and coordination in strength training. European Journal of Applied Physiology and Occupational Physiology. 1986;55(1):100-5.
  11. Bruusgaard JC, Johansen I, Egner I, Rana Z, Gundersen K. Myonuclei acquired by overload exercise precede hypertrophy and are not lost on detraining. Proceedings of the National Academy of Sciences. 2010;107(34):15111-6.
  12. Egner IM, Bruusgaard JC, Eftestøl E, Gundersen K. A cellular memory mechanism aids overload hypertrophy in muscle long after an episodic exposure to anabolic steroids. The Journal of Physiology. 2013;591(24):6221-30.
  13. Gregory TR. Coincidence, coevolution, or causation? DNA content, cell size, and the C-value enigma. Biological Reviews. 2001;76(1):65-101.
  14. Rahmati M, McCarthy JJ, Malakoutinia F. Myonuclear permanence in skeletal muscle memory: a systematic review and meta‐analysis of human and animal studies. Journal of Cachexia, Sarcopenia and Muscle. 2022;13(5):2276-97.
  15. Hansson K-A, Eftestøl E, Bruusgaard JC, Juvkam I, Cramer AW, Malthe-Sørenssen A, et al. Myonuclear content regulates cell size with similar scaling properties in mice and humans. Nature Communications. 2020;1(1):1-14.
  16. Bruusgaard J, Liestøl K, Ekmark M, Kollstad K, Gundersen K. Number and spatial distribution of nuclei in the muscle fibres of normal mice studied in vivo. The Journal of Physiology. 2003;551(2):467-78.
  17. Bruusgaard J, Liestøl K, Gundersen Distribution of myonuclei and microtubules in live muscle fibers of young, middle-aged, and old mice. Journal of Applied Physiology. 2006;100(6):2024-30.
  18. Pavlath GK, Rich K, Webster SG, Blau HM. Localization of muscle gene products in nuclear domains. Nature. 1989;337(6207):570-3.
  19. Enesco M, Puddy D. Increase in the number of nuclei and weight in skeletal muscle of rats of various ages. American Journal of Anatomy. 1964;114(2):235-44.
  20. MacConnachie H, Enesco M, Leblond C. The mode of increase in the number of skeletal muscle nuclei in the postnatal rat. American Journal of Anatomy. 1964;114(2):245-53.
  21. Reger JF, Craig AS. Studies on the fine structure of muscle fibers and associated satellite cells in hypertrophic human deltoid muscle. The Anatomical Record. 1968;162(4):483-99.
  22. Gundersen K, Bruusgaard JC. Nuclear domains during muscle atrophy: nuclei lost or paradigm lost? The Journal of Physiology. 2008;586(11):2675-81.
  23. Schwartz LM. Skeletal muscles do not undergo apoptosis during either atrophy or programmed cell death-revisiting the myonuclear domain hypothesis. Frontiers in Physiology. 2019:1887.
  24. van der Meer SF, Jaspers RT, Jones DA, Degens H. The time course of myonuclear accretion during hypertrophy in young adult and older rat plantaris muscle. Annals of Anatomy-Anatomischer Anzeiger. 2011;193(1):56-63.
  25. Gundersen K. Muscle memory and a new cellular model for muscle atrophy and hypertrophy. Journal of Experimental Biology. 2016;219(2):235-42.
  26. Bruusgaard JC, Egner IM, Larsen TK, Dupre-Aucouturier S, Desplanches D, Gundersen K. No change in myonuclear number during muscle unloading and reloading. Journal of Applied Physiology. 2012;113(2):290-6.
  27. Lee H, Kim K, Kim B, Shin J, Rajan S, Wu J, et al. A cellular mechanism of muscle memory facilitates mitochondrial remodelling following resistance training. The Journal of Physiology. 2018;596(18):4413-26.
  28. Murach KA, Mobley CB, Zdunek CJ, Frick KK, Jones SR, McCarthy JJ, et al. Muscle memory: myonuclear accretion, maintenance, morphology, and miRNA levels with training and detraining in adult mice. Journal of Cachexia, Sarcopenia and Muscle. 2020;11(6):1705-22.
  29. Guo B-S, Cheung K-K, Yeung SS, Zhang B-T, Yeung EW. Electrical stimulation influences satellite cell proliferation and apoptosis in unloading-induced muscle atrophy in mice. PloS One. 2012;7(1):e30348.
  30. Dos Santos M, Backer S, Saintpierre B, Izac B, Andrieu M, Letourneur F, et al. Single-nucleus RNA-seq and FISH identify coordinated transcriptional activity in mammalian myofibers. Nature Communications. 2020;11(1):1-16.
  31. Von Walden F, Rea M, Mobley CB, Fondufe-Mittendorf Y, McCarthy JJ, Peterson CA, et al. The myonuclear DNA methylome in response to an acute hypertrophic stimulus. Epigenetics. 2020;15(11):1151-62.
  32. McKellar DW, Walter LD, Song LT, Mantri M, Wang MF, De Vlaminck I, et al. Large-scale integration of single-cell transcriptomic data captures transitional progenitor states in mouse skeletal muscle regeneration. Communications Biology. 2021;4(1):1-12.
  33. Wen Y, Dungan CM, Mobley CB, Valentino T, von Walden F, Murach KA. Nucleus type-specific DNA methylomics reveals epigenetic “memory” of prior adaptation in skeletal muscle. Function. 2021;2(5):zqab038.
  34. Kim M, Franke V, Brandt B, Lowenstein E. Single-nucleus transcriptomics reveals functional compartmentalization in syncytial skeletal muscle cells. Spuler, S, Akalin, A and Birchmeier, C. 2020.
  35. Moro T, Brightwell CR, Volpi E, Rasmussen BB, Fry CS. Resistance exercise training promotes fiber type-specific myonuclear adaptations in older adults. Journal of Applied Physiology. 2020;128(4):795-804.
  36. Tseng BS KC, Edgerton VR. Cytoplasm-to-myonucleus ratios and succinate dehydrogenase activities in adult rat slow and fast muscle fibers. Cell Tissue Res. 1994;275:39-49.
  37. Burleigh I. Observations on the number of nuclei within the fibres of some red and white muscles. Journal of Cell Science. 1977;23(1):269-84.
  38. Davey D, Wong S. Morphometric analysis of rat extensor digitorum longus and soleus muscles. Australian Journal of Experimental Biology and Medical Science. 1980;58(3):213-30.
  39. Zak R, Rabinowitz M, Platt C. Ribonucleic acids associated with myofibrils. Biochemistry. 1967;6(8):2493-500.
  40. Frese S, Ruebner M, Suhr F, Konou TM, Tappe KA, Toigo M, et al. Long-term endurance exercise in humans stimulates cell fusion of myoblasts along with fusogenic endogenous retroviral genes in vivo. PloS One. 2015;10(7):e0132099.
  41. Fry CS, Noehren B, Mula J, Ubele MF, Westgate PM, Kern PA, et al. Fibre type‐specific satellite cell response to aerobic training in sedentary adults. The Journal of Physiology. 2014;592(12):2625-35.
  42. McKenzie AI, D'Lugos AC, Saunders MJ, Gworek KD, Luden ND. Fiber type-specific satellite cell content in cyclists following heavy training with carbohydrate and carbohydrate-protein supplementation. Frontiers in Physiology. 2016;7:550.
  43. Goh Q, Song T, Petrany MJ, Cramer AA, Sun C, Sadayappan S, et al. Myonuclear accretion is a determinant of exercise-induced remodeling in skeletal muscle. Elife. 2019;8:e44876.
  44. Kurosaka M, Naito H, Ogura Y, Kojima A, Goto K, Katamoto S. Effects of voluntary wheel running on satellite cells in the rat plantaris muscle. Journal of Sports Science and Medicine. 2009;8(1):51-7.
  45. Smith HK, Maxwell L, Rodgers CD, McKee NH, Plyley MJ. Exercise-enhanced satellite cell proliferation and new myonuclear accretion in rat skeletal muscle. Journal of Applied Physiology. 2001;90(4):1407-14.
  46. Bjørnsen T, Wernbom M, Løvstad A, Paulsen G, D’Souza RF, Cameron-Smith D, et al. Delayed myonuclear addition, myofiber hypertrophy, and increases in strength with high-frequency low-load blood flow restricted training to volitional failure. Journal of Applied Physiology. 2019;126(3):578-92.
  47. Mobley C, Holland A, Kephart W, Mumford P, Lowery R, Kavazis A, et al. Progressive resistance‐loaded voluntary wheel running increases hypertrophy and differentially affects muscle protein synthesis, ribosome biogenesis, and proteolytic markers in rat muscle. Journal of Animal Physiology and Animal Nutrition. 2018;102(1):317-29.
  48. Snijders T, Smeets JS, Van Kranenburg J, Kies A, van Loon L, Verdijk LB. Changes in myonuclear domain size do not precede muscle hypertrophy during prolonged resistance‐type exercise training. Acta Physiologica. 2016;216(2):231-9.
  49. Petrella JK, Kim J-s, Mayhew DL, Cross JM, Bamman MM. Potent myofiber hypertrophy during resistance training in humans is associated with satellite cell-mediated myonuclear addition: a cluster analysis. Journal of Applied Physiology. 2008;104(6):1736-42.
  50. Snijders T, Holwerda AM, van Loon LJ, Verdijk LB. Myonuclear content and domain size in small versus larger muscle fibres in response to 12 weeks of resistance exercise training in older adults. Acta Physiologica. 2021;231(4):e13599.
  51. Dungan CM, Brightwell CR, Wen Y, Zdunek CJ, Latham CM, Thomas NT, et al. Muscle-specific cellular and molecular adaptations to late-life voluntary concurrent exercise. Function. 2022;3(4):zqac027.
  52. Murach KA, Fry CS, Dupont‐Versteegden EE, McCarthy JJ, Peterson CA. Fusion and beyond: Satellite cell contributions to loading‐induced skeletal muscle adaptation. The FASEB Journal. 2021;35(10):e21893.
  53. Masschelein E, D’Hulst G, Zvick J, Hinte L, Soro-Arnaiz I, Gorski T, et al. Exercise promotes satellite cell contribution to myofibers in a load-dependent manner. Skeletal muscle. 2020;10(1):1-15.
  54. Murach KA, Peck BD, Policastro RA, Vechetti IJ, Van Pelt DW, Dungan CM, et al. Early satellite cell communication creates a permissive environment for long-term muscle growth. IScience. 2021;24(4):102372.
  55. Murach KA, Dungan CM, von Walden F, Wen Y. Epigenetic evidence for distinct contributions of resident and acquired myonuclei during long-term exercise adaptation using timed in vivo myonuclear labeling. American Journal of Physiology-Cell Physiology. 2022;322(1):C86-C93.
  56. Hansson K-A, Solbrå AV, Gundersen K, Bruusgaard JC. Computational assessment of transport distances in living skeletal muscle fibers studied in situ. Biophysical Journal. 2020;119(11):2166-78.
  57. Azevedo M, Baylies MK. Getting into position: nuclear movement in muscle cells. Trends in Cell Biology. 2020;30(4):303-16.
  58. Kirby TJ, Lammerding J. Emerging views of the nucleus as a cellular mechanosensor. Nature Cell Biology. 2018;20(4):373-81.
  59. Folker ES, Baylies MK. Nuclear positioning in muscle development and disease. Frontiers in Physiology. 2013;4:363.
  60. Roman W, Pinheiro H, Pimentel MR, Segalés J, Oliveira LM, García-Domínguez E, et al. Muscle repair after physiological damage relies on nuclear migration for cellular reconstruction. Science. 2021;374(6565):355-9.
  61. Glancy B, Hsu LY, Dao L, Bakalar M, French S, Chess DJ, et al. In vivo microscopy reveals extensive embedding of capillaries within the sarcolemma of skeletal muscle fibers. Microcirculation. 2014;21(2):131-47.
  62. Willingham TB, Ajayi PT, Glancy B. Subcellular specialization of mitochondrial form and function in skeletal muscle cells. Frontiers in Cell and Developmental 2021;9.
  63. Buckley KH, Nestor-Kalinoski AL, Pizza FX. Positional Context of Myonuclear Transcription During Injury-Induced Muscle Regeneration. Frontiers in Physiology. 2022;13.
  64. Rader EP, Baker BA. Elevated muscle mass accompanied by transcriptional and nuclear alterations several months following cessation of resistance‐type training in rats. Physiological Reports. 2022;10(20):e15476.
  65. Snijders T, Aussieker T, Holwerda A, Parise G, van Loon LJ, Verdijk LB. The concept of skeletal muscle memory: Evidence from animal and human studies. Acta Physiologica. 2020;229(3):e13465.
  66. Schwartz L, Gundersen K. Cross Talk rebuttal: Schwartz and Gundersen. The Journal of Physiology. 2022;600(9):2087-8.
  67. Kirby TJ, Dupont-Versteegden EE. Cross Talk rebuttal: Kirby and Dupont-Versteegden. The Journal of Physiology. 2022;600(9):2085-6.
  68. Ross JA, Pearson A, Levy Y, Cardel B, Handschin C, Ochala J. Exploring the role of PGC‐1α in defining nuclear organisation in skeletal muscle fibres. Journal of Cellular Physiology. 2017;232(6):1270-4.
  69. SATRON R. Strength and skeletal muscle adaptations in heavy-resistance-trained women after detraining and retrainig. J Appl Physiol. 1991;70:631-40.
  70. Schwartz LM, Gundersen K. Cross Talk opposing view: Myonuclei do not undergo apoptosis during skeletal muscle atrophy. The Journal of Physiology. 2022;600(9):2081-4.
  71. Iwata M, Englund DA, Wen Y, Dungan CM, Murach KA, Vechetti IJ, et al. A novel tetracycline-responsive transgenic mouse strain for skeletal muscle-specific gene expression. Skeletal Muscle. 2018;8(1):1-8.
  72. Aravamudan B, Mantilla CB, Zhan W-Z, Sieck GC. Denervation effects on myonuclear domain size of rat diaphragm fibers. Journal of Applied Physiology. 2006;100(5):1617-22.
  73. Viguie CA, Lu DX, Huang SK, Rengen H, Carlson BM. Quantitative study of the effects of long‐term denervation on the extensor digitorum longus muscle of the rat. The Anatomical Record: An Official Publication of the American Association of Anatomists. 1997;248(3):346-54.
  74. Borisov AB, Carlson BM. Cell death in denervated skeletal muscle is distinct from classical apoptosis. The Anatomical Record: An Official Publication of the American Association of Anatomists. 2000;258(3):305-18.
  75. Schmalbruch H, Lewis D. Dynamics of nuclei of muscle fibers and connective tissue cells in normal and denervated rat muscles. Muscle & Nerve: Official Journal of the American Association of Electrodiagnostic Medicine. 2000;23(4):617-26.
  76. Dupont-Versteegden EE, Murphy RJ, Houlé JD, Gurley CM, Peterson CA. Activated satellite cells fail to restore myonuclear number in spinal cord transected and exercised rats. American Journal of Physiology-Cell Physiology. 1999;277(3):C589-C97.
  77. Dupont-Versteegden EE, Murphy RJ, Houlé JD, Gurley CM, Peterson CA. Mechanisms leading to restoration of muscle size with exercise and transplantation after spinal cord injury. American Journal of Physiology-Cell Physiology. 2000;279(6):C1677-C84.
  78. Darr KC, Schultz E. Hindlimb suspension suppresses muscle growth and satellite cell proliferation. Journal of Applied Physiology. 1989;67(5):1827-34.
  79. Allen D, Monke S, Talmadge R, Roy R, Edgerton V. Plasticity of myonuclear number in hypertrophied and atrophied mammalian skeletal muscle fibers. Journal of Applied Physiology. 1995;78(5):1969-76.
  80. Allen DL, Linderman JK, Roy RR, Grindeland RE, Mukku V, Edgerton VR. Growth hormone/IGF-I and/or resistive exercise maintains myonuclear number in hindlimb unweighted muscles. Journal of Applied Physiology. 1997;83(6):1857-61.
  81. Leeuwenburgh C, Gurley CM, Strotman BA, Dupont-Versteegden EE. Age-related differences in apoptosis with disuse atrophy in soleus muscle. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 2005;288(5):R96-
  82. Matsuba Y, Goto K, Morioka S, Naito T, Akema T, Hashimoto N, et al. Gravitational unloading inhibits the regenerative potential of atrophied soleus muscle in mice. Acta Physiologica. 2009;196(3):329-39.
  83. Allen D, Yasui W, Tanaka T, Ohira Y, Nagaoka S, Sekiguchi C, et al. Myonuclear number and myosin heavy chain expression in rat soleus single muscle fibers after spaceflight. Journal of Applied Physiology. 1996;81(1):145-51.
  84. Hikida RS, van Nostran S, Murray JD, Staron RS, Gordon SE, Kraemer WJ. Myonuclear loss in atrophied soleus muscle fibers. The Anatomical Record: An Official Publication of the American Association of Anatomists. 1997;247(3):350-4.
  85. Sandonà D, Desaphy J-F, Camerino GM, Bianchini E, Ciciliot S, Danieli-Betto D, et al. Adaptation of mouse skeletal muscle to long-term microgravity in the MDS mission. PloS One. 2012;7(3):e33232.
  86. Bruusgaard JC, Gundersen K. In vivo time-lapse microscopy reveals no loss of murine myonuclei during weeks of muscle atrophy. The Journal of Clinical Investigation. 2008;118(4):1450-7.
  87. Winje I, Bengtsen M, Eftestøl E, Juvkam I, Bruusgaard JC, Gundersen K. Specific labelling of myonuclei by an antibody against pericentriolar material 1 on skeletal muscle tissue sections. Acta Physiologica. 2018;223(4):e13034.
  88. Winje IM, Sheng X, Hansson KA, Solbrå A, Tennøe S, Saatcioglu F, et al. Cachexia does not induce loss of myonuclei or muscle fibres during xenografted prostate cancer in mice. Acta Physiologica. 2019;225(3):e13204.
  89. Adhihetty PJ, O'Leary MF, Chabi B, Wicks KL, Hood DA. Effect of denervation on mitochondrially mediated apoptosis in skeletal muscle. Journal of Applied Physiology. 2007;102(3):1143-51.
  90. Dungan CM, Murach KA, Frick KK, Jones SR, Crow SE, Englund DA, et al. Elevated myonuclear density during skeletal muscle hypertrophy in response to training is reversed during detraining. American Journal of Physiology-Cell Physiology. 2019;316(5):C649-C54.
  91. Jin H, Wu Z, Tian T, Gu Y. Apoptosis in atrophic skeletal muscle induced by brachial plexus injury in rats. Journal of Trauma and Acute Care Surgery. 2001;50(1):31-5.
  92. Jackson JR, Mula J, Kirby TJ, Fry CS, Lee JD, Ubele MF, et al. Satellite cell depletion does not inhibit adult skeletal muscle regrowth following unloading-induced atrophy. American Journal of Physiology-Cell Physiology. 2012;303(8):C854-C61.
  93. Kasper CE, Xun L. Cytoplasm-to-myonucleus ratios in plantaris and soleus muscle fibres following hindlimb suspension. Journal of Muscle Research & Cell Motility. 1996;17(5):603-10.
  94. Kasper CE, Xun L. Cytoplasm-to-myonucleus ratios following microgravity. Journal of Muscle Research & Cell Motility. 1996;17(5):595-602.
  95. Mozdziak P, Pulvermacher P, Schultz E. Unloading of juvenile muscle results in a reduced muscle size 9 wk after reloading. Journal of Applied Physiology. 2000;88(1):158-64.
  96. Zhong H, Roy RR, Siengthai B, Edgerton VR. Effects of inactivity on fiber size and myonuclear number in rat soleus muscle. Journal of Applied Physiology. 2005;99(4):14.
  97. Lee G, Lim JY, Frontera WR. Apoptosis in young and old denervated rat skeletal muscle. Muscle & Nerve. 2017;55(2):262-9.
 

 

  1. Hao Y, Jackson JR, Wang Y, Edens N, Pereira SL, Alway SE. β-Hydroxy-β-methylbutyrate reduces myonuclear apoptosis during recovery from hind limb suspension-induced muscle fiber atrophy in aged rats. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 2011;301(3):R701-R15.
  2. Lim JY, Han TR. Effect of electromyostimulation on apoptosis‐related factors in denervation and reinnervation of rat skeletal muscles. Muscle & Nerve. 2010;42(3):422-30.
 

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