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بابایی, فاطمه, برزگری, علی, نوریان, ابراهیم, دشتی خویدکی, محمد حسن. (1401). بررسی اثر 12 هفته تمرین شنای زیر بیشینه بر نشانگرهای زیستی MAPK و MDA در موش های صحرایی در معرض نیتروزآمین کتون مشتق از تنباکو. , 14(56), 147-176. doi: 10.22089/spj.2022.12495.2185
فاطمه بابایی; علی برزگری; ابراهیم نوریان; محمد حسن دشتی خویدکی. "بررسی اثر 12 هفته تمرین شنای زیر بیشینه بر نشانگرهای زیستی MAPK و MDA در موش های صحرایی در معرض نیتروزآمین کتون مشتق از تنباکو". , 14, 56, 1401, 147-176. doi: 10.22089/spj.2022.12495.2185
بابایی, فاطمه, برزگری, علی, نوریان, ابراهیم, دشتی خویدکی, محمد حسن. (1401). 'بررسی اثر 12 هفته تمرین شنای زیر بیشینه بر نشانگرهای زیستی MAPK و MDA در موش های صحرایی در معرض نیتروزآمین کتون مشتق از تنباکو', , 14(56), pp. 147-176. doi: 10.22089/spj.2022.12495.2185
بابایی, فاطمه, برزگری, علی, نوریان, ابراهیم, دشتی خویدکی, محمد حسن. بررسی اثر 12 هفته تمرین شنای زیر بیشینه بر نشانگرهای زیستی MAPK و MDA در موش های صحرایی در معرض نیتروزآمین کتون مشتق از تنباکو. , 1401; 14(56): 147-176. doi: 10.22089/spj.2022.12495.2185

بررسی اثر 12 هفته تمرین شنای زیر بیشینه بر نشانگرهای زیستی MAPK و MDA در موش های صحرایی در معرض نیتروزآمین کتون مشتق از تنباکو

فیزیولوژی ورزشی
مقاله 6، دوره 14، شماره 56، بهمن 1401، صفحه 147-176    اصل مقاله (695.09 K)
نوع مقاله: مقاله پژوهشی
شناسه دیجیتال (DOI): 10.22089/spj.2022.12495.2185
نویسندگان
فاطمه بابایی1؛ علی برزگری* 2؛ ابراهیم نوریان3؛ محمد حسن دشتی خویدکی3
1کارشناس ارشد، گروه تربیت بدنی و علوم ورزشی، دانشگاه پیام نور، صندوق پستی 3697-19395 تهران، ایران
2عضو هیات علمی دانشگاه پیام نور
3گروه فیزیولوژی ورزش ، دانشگاه پیام نور، تهران صندوق پستی 3697-19395، ایران.
چکیده
هدف و زمینه:هدف از پژوهش حاضر بررسی اثر 12 هفته تمرین شنای زیر بیشینه بر نشانگرهای زیستی MAPK و MDA در موش های صحرایی در معرض نیتروزآمین کتون مشتق از تنباکو بود.
روش پژوهش: 48 سر موش صحرایی نژاد ویستار 8-6 هفته ای با محدوده وزنی 26 ± 105 گرم خریداری و به طور تصادفی به 5 گروه کنترل (8 سر)،تزریق آب مقطر (10 سر)،تزریقNNK (10سر)،تمرین شنا (10 سر)،تمرین شنا + تزریق NNK (10سر)، تقسیم شدند. برنامه تمرینی شامل 12 هفته تمرین شنا با شدت زیر بیشینه (پنج روز در هفته) بود. 48 ساعت پس از آخرین جلسه تمرین نمونه‌گیری از بافت ریه انجام شد و سطوح نشانگرهای MAPK و MDA بافت ریه با تکنیک الایزا، اندازه گیری شد. جهت تجزیه و تحلیل داده ها از آنالیز واریانس یک طرفه و توکی استفاده شد.
نتایج: نتایج نشان داد میزان MAPK (001/0P= ) وMDA(000/0P= )در بین گروه ‌ها معنی دار بود.نتایج آزمون توکی نشان داد که کاهش MAPK در گروه‌های شنا و شنا + مداخله NNK نسبت به گروه مداخله NNK معنی‌دار بود(001/0=P)(001/0=P) و همچنین، میزان کاهش MDA در گروه-های شنا و شنا + مداخله NNK نسبت به گروه مداخله NNK معنی‌دار بود (001/0=P)(001/0=P).
نتیجه گیری:نتایج مطالعات نشان دادند،تمرین شنا می‌تواند تا حدودی آثار منفی NNK بر سطوح MAPK و MDA را کاهش دهد و این احتمال وجود دارد که با توجه به نقش ضدالتهابی فعالیت ورزشی شنا بتواند اثر کارسینوژنیک NNK را کنترل و در محافظت از سیستم تنفسی در برابر ماده سرطان‌زای NNK تاثیر گذار باشد.
کلیدواژه‌ها
تمرین شنا؛ ریه؛ NNK؛ MAPK؛ MDA
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