ملانوری شمسی, مهدیه, امانی, صادق. (1399). فعالیت ورزشی، سیستم ایمنی و کروناویروس. , 12(46), 17-40. doi: 10.22089/spj.2020.9033.2038
مهدیه ملانوری شمسی; صادق امانی. "فعالیت ورزشی، سیستم ایمنی و کروناویروس". , 12, 46, 1399, 17-40. doi: 10.22089/spj.2020.9033.2038
ملانوری شمسی, مهدیه, امانی, صادق. (1399). 'فعالیت ورزشی، سیستم ایمنی و کروناویروس', , 12(46), pp. 17-40. doi: 10.22089/spj.2020.9033.2038
ملانوری شمسی, مهدیه, امانی, صادق. فعالیت ورزشی، سیستم ایمنی و کروناویروس. , 1399; 12(46): 17-40. doi: 10.22089/spj.2020.9033.2038

فعالیت ورزشی، سیستم ایمنی و کروناویروس

فیزیولوژی ورزشی
مقاله 1، دوره 12، شماره 46، تیر 1399، صفحه 17-40    اصل مقاله (493.97 K)
نوع مقاله: مقاله مروری
شناسه دیجیتال (DOI): 10.22089/spj.2020.9033.2038
نویسندگان
مهدیه ملانوری شمسی1؛ صادق امانی* 2
1دانشیار فیزیولوژی ورزشی، دانشگاه تربیت مدرس، تهران
2استادیار فیزیولوژی ورزشی، دانشگاه خوارزمی، تهران
چکیده
سندروم حاد تنفسی جدید یعنی کروناویروس-دو (SARS-CoV2)، ایجادکنندة بیماری کووید 19 (COVID-19) به‌عنوان یک بیماری همه‌گیر تهدیدکنندة جوامع بشری از جنبه­های متفاوت است. به‌نظر می­رسد درحال‌حاضر، راهبرد اصلی مدیریت کروناویروس پیشگیری از ابتلا به آن است. فعالیت­های ورزشی با شدت متوسط علاوه‌بر ارتقای آمادگی جسمانی، باعث تقویت پاسخ­های سیستم ایمنی سلولی و هومورال به‌ویژه در افراد با ضعف سیستم ایمنی درمعرض خطر عوارض کروناویروس مانند افراد مسن، افراد چاق و دارای بیماری­های مزمن می­‌شوند؛ بنابراین، انجام‌دادن فعالیت­های ورزشی به‌صورت منظم در طول عمر می‌تواند راهبردی مؤثر برای پیشگیری از بیماری ویروسی مانند کووید-19 باشد. ازطرفی، قرنطینة خانگی و استفاده‌نکردن از اماکن ورزشی عمومی باعث کاهش میزان آمادگی جسمانی، اختلال در ریتم شبانه‌روزی، اختلال در خواب، افسردگی، افزایش رفتارهای بی‌تحرکانه و برهم‌خوردن تعادل انرژی دریافتی و مصرفی می­شوند که تمامی این موارد با ضعف سیستم ایمنی و خطر عوارض شدیدتر حاصل از بیماری کووید 19 همراه‌اند. فعالیت بدنی با شدت متوسط در خانه در زمان شیوع این بیماری می­تواند راهبردی مؤثر در مقابله با این عوارض ­باشد. همچنین، فعالیت بدنی با شدت متوسط به‌صورت مستقیم از طریق تقویت سیستم ایمنی، ارتقای دفاع آنتی‌اکسیدانتی و تقویت پاسخ­های ضدالتهابی و نیز به‌صورت غیرمستقیم از طریق کاهش اضطراب، بهبود خلق‌‌وخو، تعدیل نیم‌رخ چربی و حساسیت انسولینی، در ارتقای سیستم ایمنی و مقابله با عوارض کروناویروس مؤثر است.
کلیدواژه‌ها
بیماری کووید-19؛ ورزش در خانه؛ عفونت مجاری فوقانی تنفسی؛ عفونت ویروسی؛ فعالیت هوازی؛ لکوسیت
مراجع
  1. Molanouri Shamsi M, Hassan ZM, Gharakhanlou R. Exercise-Induced Chaperokine Activity of Hsp70: Possible Role in Chronic Diseases. In: Asea AAA, Kaur P, editors. Chaperokine Activity of Heat Shock Proteins. Cham: Springer International Publishing; 2019. p. 193-209.
  2. Gleeson M, Bishop N, Walsh N. Exercise Immunology. 1st ed. London: Routledge; 2013. p. 17-43.
  3. Ferkol T, Schraufnagel D. The global burden of respiratory disease. Ann Am Thorac Soc. 2014;11(3):404-6.
  4. Nieman DC. Coronavirus disease-2019: A tocsin to our aging, unfit, corpulent, and immunodeficient society. J Sport Health Sci. 2020;9(4):293-301.
  5. Fung SY, Yuen KS, Ye ZW, Chan CP, Jin DY. A tug-of-war between severe acute respiratory syndrome coronavirus 2 and host antiviral defence: lessons from other pathogenic viruses. Emerg Microbes Infect. 2020;9(1):558-70.
  6. Tay MZ, Poh CM, Rénia L, MacAry PA, Ng LFP. The trinity of COVID-19: immunity, inflammation and intervention. Nat Rev Immunol. 2020;20(6):363-74.
  7. Qin G, Zhang L, Yu CJ. Nonpharmaceutical interventions and epidemic intensity during the 2019 novel coronavirus disease pandemic. Clin Infect Dis. 2020; Inpress.
  8. Moon SL, Wilusz J. Cytoplasmic viruses: rage against the (cellular RNA decay) machine. PLoS Pathog. 2013;9(12):e1003762-e.
  9. Mogensen TH, Paludan SR. Molecular pathways in virus-induced cytokine production. Microbiol Mol Biol Rev. 2001;65(1):131-50.
  10. Siu K-L, Chan C-P, Kok K-H, Woo PC-Y, Jin D-Y. Suppression of innate antiviral response by severe acute respiratory syndrome coronavirus M protein is mediated through the first transmembrane domain. Cell Mol Immunol. 2014;11(2):141-9.
  11. Abbas AK, Lichtman AH, Pillai S. Basic immunology: functions and disorders of the immune system. Fifth ed. St. Louis, Missouri: Elsevier; 2016. p. 17-43.
  12. Yang L-T, Peng H, Zhu Z-L, Li G, Huang Z-T, Zhao Z-X, et al. Long-lived effector/central memory T-cell responses to severe acute respiratory syndrome coronavirus (SARS-CoV) S antigen in recovered SARS patients. Clin Immunol. 2006;120(2):171-8.
  13. Monto AS, DeJonge P, Callear AP, Bazzi LA, Capriola S, Malosh RE, et al. Coronavirus occurrence and transmission over 8 years in the HIVE cohort of households in Michigan. J Infect Dis. 2020;222(1):9-16.
  14. Li Q, Guan X, Wu P, Wang X, Zhou L, Tong Y, et al. Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus-Infected Pneumonia. N Engl J Med. 2020;382(13):1199-207.
  15. Lauer SA, Grantz KH, Bi Q, Jones FK, Zheng Q, Meredith HR, et al. The Incubation Period of Coronavirus Disease 2019 (COVID-19) From Publicly Reported Confirmed Cases: Estimation and Application. Ann Intern Med. 2020;172(9):577-82.
  16. Peiris JS, Chu CM, Cheng VC, Chan KS, Hung IF, Poon LL, et al. Clinical progression and viral load in a community outbreak of coronavirus-associated SARS pneumonia: a prospective study. Lancet. 2003;361(9371):1767-72.
  17. Wang W, Xu Y, Gao R, Lu R, Han K, Wu G, et al. Detection of SARS-CoV-2 in Different Types of Clinical Specimens. JAMA. 2020;323(18):1843-4.
  18. Peeri NC, Shrestha N, Rahman MS, Zaki R, Tan Z, Bibi S, et al. The SARS, MERS and novel coronavirus (COVID-19) epidemics, the newest and biggest global health threats: what lessons have we learned? Int J Epidemiol. 2020;49(3):717-26.
  19. Novel CPERE. The epidemiological characteristics of an outbreak of 2019 novel coronavirus diseases (COVID-19) in China. Zhonghua Liu Xing Bing Xue Za Zhi. 2020;41(2):145-51.
  20. King AJ, Burke LM, Halson SL, Hawley JA. The Challenge of Maintaining Metabolic Health During a Global Pandemic. Sports Med. 2020;50(7):1233-41.
  21. Wheeler MJ, Dempsey PC, Grace MS, Ellis KA, Gardiner PA, Green DJ, et al. Sedentary behavior as a risk factor for cognitive decline? A focus on the influence of glycemic control in brain health. Alzheimers Dement (N Y). 2017;3(3):291-300.
  22. World Health Organization. Global recommendations on physical activity for health: World Health Organization; 2010. p. 20.
  23. Duggal NA, Niemiro G, Harridge SDR, Simpson RJ, Lord JM. Can physical activity ameliorate immunosenescence and thereby reduce age-related multi-morbidity? Nat Rev Immunol. 2019;19(9):563-72.
  24. Simpson RJ, Lowder TW, Spielmann G, Bigley AB, LaVoy EC, Kunz H. Exercise and the aging immune system. Ageing Res Rev. 2012;11(3):404-20.
  25. Nikpouraghdam M, Jalali Farahani A, Alishiri G, Heydari S, Ebrahimnia M, Samadinia H, et al. Epidemiological characteristics of coronavirus disease 2019 (COVID-19) patients in IRAN: A single center study. J Clin Virol. 2020;127:104378.
  26. Amani-Shalamzari S, Hamid A-A, Gharakhanlou R, Molanouri-Shamsi M, Talebi Badrabadi K. The effect of body composition and physical activity on basal levels of insulin, glucose, IL-18, IL-6 & CRP and their relationship with insulin resistance. Iranian Journal of Endocrinology & Metabolism. 2009;11(6):699-707. (In Persian).
  27. Milner JJ, Beck MA. The impact of obesity on the immune response to infection. Proc Nutr Soc. 2012;71(2):298-306.
  28. Simonnet A, Chetboun M, Poissy J, Raverdy V, Noulette J, Duhamel A, et al. High prevalence of obesity in severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) requiring invasive mechanical ventilation. Obesity (Silver Spring). 2020;28(7):1195-9.
  29. Maier HE, Lopez R, Sanchez N, Ng S, Gresh L, Ojeda S, et al. Obesity increases the duration of influenza a virus shedding in adults. J Infect Dis. 2018;218(9):1378-82.
  30. Molanouri Shamsi M, Najedi S, Hassan ZM, Isanejad A, Mahdavi M. Short term exercise training enhances cell-mediated responses to HSV-1 vaccine in mice. Microb Pathog. 2017;110:457-63.
  31. Bhatia RT, Marwaha S, Malhotra A, Iqbal Z, Hughes C, Börjesson M, et al. Exercise in the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) era: A Question and Answer session with the experts Endorsed by the section of Sports Cardiology & Exercise of the European Association of Preventive Cardiology (EAPC). Eur J Prev Cardiol. 2020;27(12):1242-51.
  32. Simpson RJ, Kunz H, Agha N, Graff R. Exercise and the Regulation of Immune Functions. Prog Mol Biol Transl Sci. 2015;135:355-80.
  33. Nieman DC, Henson DA, Austin MD, Brown VA. Immune response to a 30-minute walk. Med Sci Sports Exerc. 2005;37(1):57-62.
  34. LaVoy EC, Bollard CM, Hanley PJ, Blaney JW, O'Connor DP, Bosch JA, et al. A single bout of dynamic exercise enhances the expansion of MAGE-A4 and PRAME-specific cytotoxic T-cells from healthy adults. Exerc Immunol Rev. 2015;21:144-53.
  35. Ghaderi M, Azarbayjani M, Atashak S, Molanouri-Shamsi M, Mokari-Saei S, Sharafi H. The Effect of maximal progressive exercise on serum cortisol & immunoglobulin a responses in young elite athletes. Ann Biol Res. 2011;2(6):456-63.
  36. Gorzi A, Rajabi H, Azad A, Molanouri Shamsi M, Hedayati M. Effect of Concurrent, Strength and Endurance Training on Hormones, Lipids and Inflammatory Characteristics of Untrained Men. Iranian Journal of Endocrinology and Metabolism. 2012;13(6):614-20. (In Persian).
  37. Ferrandi PJ, Fico BG, Whitehurst M, Zourdos MC, Bao F, Dodge KM, et al. Acute high-intensity interval exercise induces comparable levels of circulating cell-free DNA and Interleukin-6 in obese and normal-weight individuals. Life Sci. 2018;202:161-6.
  38. Molanouri Shamsi, Alinejad, Amani Shalamzari, Aghayari, Asghari Jafarabadi, Talebi Badrabadi. Anti-Inflammatory Effects of a Bout of Circuit Resistance Exercise With Moderateintensity in Inactive Obese Males. The Journal of Shahid Sadoughi University of Medical Sciences. 2011;19(5):598-609. (In Persian).
  39. Adams GR, Zaldivar FP, Nance DM, Kodesh E, Radom-Aizik S, Cooper DM. Exercise and leukocyte interchange among central circulation, lung, spleen, and muscle. Brain Behav Immun. 2011;25(4):658-66.
  40. Rezaei S, Shamsi MM, Mahdavi M, Jamali A, Prestes J, Tibana RA, et al. Endurance exercise training decreased serum levels of surfactant protein D and improved aerobic fitness of obese women with type-2 diabetes. Diabetol Metab Syndr. 2017;9:74.
  41. Grande AJ, Reid H, Thomas EE, Nunan D, Foster C. Exercise prior to influenza vaccination for limiting influenza incidence and its related complications in adults. Cochrane Database Syst Rev. 2016(8):Cd011857.
  42. Molanouri Shamsi M, Jamali A. Adjuvant effect of an acute moderate endurance exercise in herpes simplex virus 1 vaccination and its boosters on interleukin 10 cytokine and granzyme B in mice. Tehran University Medical Journal. 2018;76(2):96-102. (In Persian).
  43. Peters EM, Bateman ED. Ultramarathon running and upper respiratory tract infections. An epidemiological survey. S Afr Med J. 1983;64(15):582-4.
  44. Peake JM, Neubauer O, Della Gatta PA, Nosaka K. Muscle damage and inflammation during recovery from exercise. J Appl Physiol (1985). 2017;122(3):559-70.
  45. Isanejad A, Saraf ZH, Mahdavi M, Gharakhanlou R, Shamsi MM, Paulsen G. The effect of endurance training and downhill running on the expression of IL-1β, IL-6, and TNF-α and HSP72 in rat skeletal muscle. Cytokine. 2015;73(2):302-8.
  46. Campbell JP, Turner JE. Debunking the Myth of Exercise-Induced Immune Suppression: Redefining the Impact of Exercise on Immunological Health Across the Lifespan. Front Immunol. 2018;9:648.
  47. Molanouri Shamsi M, Hassan ZM, Quinn LS, Gharakhanlou R, Baghersad L, Mahdavi M. Time course of IL-15 expression after acute resistance exercise in trained rats: effect of diabetes and skeletal muscle phenotype. Endocrine. 2015;49(2):396-403.
  48. Jamali A, Molanouri- Shamsi M, Soleimanjahi H, Afshoonpour MT. Assessment of Changes in Autophagy Factors in Time Courses of Acute Exhaustive Endurance Exercise in Tibialis Anterior Skeletal Muscle of BALB/c Mice. Journal of Applied Exercise Physiology. 2019;15(29):133-42. (In Persian).
  49. Kakanis MW, Peake J, Brenu EW, Simmonds M, Gray B, Hooper SL, et al. The open window of susceptibility to infection after acute exercise in healthy young male elite athletes. Exerc Immunol Rev. 2010;16:119-37.
  50. Nieman DC, Lila MA, Gillitt ND. Immunometabolism: A Multi-Omics Approach to Interpreting the Influence of Exercise and Diet on the Immune System. Annu Rev Food Sci Technol. 2019;10:341-63.
  51. Markworth JF, Maddipati KR, Cameron-Smith D. Emerging roles of pro-resolving lipid mediators in immunological and adaptive responses to exercise-induced muscle injury. Exerc Immunol Rev. 2016;22:110-34.
  52. Nieman DC, Groen AJ, Pugachev A, Vacca G. Detection of Functional Overreaching in Endurance Athletes Using Proteomics. Proteomes. 2018;6(3):33.
  53. Nieman DC, Gillitt ND, Sha W, Esposito D, Ramamoorthy S. Metabolic recovery from heavy exertion following banana compared to sugar beverage or water only ingestion: A randomized, crossover trial. PLoS One. 2018;13(3):e0194843.
  54. Nieman DC. Is infection risk linked to exercise workload? Med Sci Sports Exerc. 2000;32(7 Suppl):S406-11.
  55. Schwellnus M, Soligard T, Alonso JM, Bahr R, Clarsen B, Dijkstra HP, et al. How much is too much? (Part 2) International Olympic Committee consensus statement on load in sport and risk of illness. Br J Sports Med. 2016;50(17):1043-52.
  56. Nieman DC, Henson DA, Austin MD, Sha W. Upper respiratory tract infection is reduced in physically fit and active adults. Br J Sports Med. 2011;45(12):987-92.
  57. Williams PT. Reduced total and cause-specific mortality from walking and running in diabetes. Med Sci Sports Exerc. 2014;46(5):933-9.
  58. Lau HM, Ng GY, Jones AY, Lee EW, Siu EH, Hui DS. A randomised controlled trial of the effectiveness of an exercise training program in patients recovering from severe acute respiratory syndrome. Aust J Physiother. 2005;51(4):213-9.
  59. Kohut ML, Arntson BA, Lee W, Rozeboom K, Yoon KJ, Cunnick JE, et al. Moderate exercise improves antibody response to influenza immunization in older adults. Vaccine. 2004;22(17-18):2298-306.
  60. Valacchi G, Virgili F, Cervellati C, Pecorelli A. OxInflammation: From Subclinical Condition to Pathological Biomarker. Front Physiol. 2018;9:858.
  61. Lal Sazegar A, Gholami M, Amani Shalamzari S. Effects of Six Week Iso-Volume Continuous and Interval Endurance Training on some Inflammatory and Lipid Profiles in Obese and Overweight Soldiers. J Mil Med. 2020;22(S1):9-17. (In Persian).
  62. Wedell-Neergaard AS, Krogh-Madsen R, Petersen GL, Hansen Å M, Pedersen BK, Lund R, et al. Cardiorespiratory fitness and the metabolic syndrome: Roles of inflammation and abdominal obesity. PLoS One. 2018;13(3):e0194991.
  63. Koelwyn GJ, Wennerberg E, Demaria S, Jones LW. Exercise in Regulation of Inflammation-Immune Axis Function in Cancer Initiation and Progression. Oncology (Williston Park). 2015;29(12):908-20.
  64. Molanouri Shamsi M, Chekachak S, Soudi S, Gharakhanlou R, Quinn LS, Ranjbar K, et al. Effects of exercise training and supplementation with selenium nanoparticle on T-helper 1 and 2 and cytokine levels in tumor tissue of mice bearing the 4 T1 mammary carcinoma. Nutrition. 2019;57:141-7.
  65. Molanouri Shamsi M, Chekachak S, Soudi S, Quinn LS, Ranjbar K, Chenari J, et al. Combined effect of aerobic interval training and selenium nanoparticles on expression of IL-15 and IL-10/TNF-α ratio in skeletal muscle of 4T1 breast cancer mice with cachexia. Cytokine. 2017;90:100-8.
  66. Mokhtarzade M, Ranjbar R, Majdinasab N, Patel D, Molanouri Shamsi M. Effect of aerobic interval training on serum IL-10, TNFα, and adipokines levels in women with multiple sclerosis: possible relations with fatigue and quality of life. Endocrine. 2017;57(2):262-71.
  67. Amani-Shalamzari S, Aghaalinejad H, Alizadeh S, Kazmi A, Saei MA, Minayi N, et al. The effect of endurance training on the level of tissue IL-6 and VEGF in mice with breast cancer. J Shahrekord Univ Med Sci. 2014;16(2):10-21. (In Persian).
  68. Agha-Alinejad H, Saei MA, Mahdavi M, Amani-Shalamzari S, Kazemi A, Pirayesh M. The effect of 6 weeks endurance training on some intra-tumor cytokines in female mice with breast cancer. Journal of Sport Biosciences. 2015;6(4):483-93. (In Persian).
  69. 6Khori V, Amani Shalamzari S, Isanejad A, Alizadeh AM, Alizadeh S, Khodayari S, et al. Effects of exercise training together with tamoxifen in reducing mammary tumor burden in mice: Possible underlying pathway of miR-21. Eur J Pharmacol. 2015;765:179-87.
  70. Shiri Y, Agha-Alinejad H, Gharakhanlou R, Amani Shalamzari S, Saei MA. Effect of six weeks endurance training on tumor tissue IL-10 cytokine levels in breast cancer bearing mice. Iranian Journal of Endocrinology and Metabolism. 2014;16(3):205-10. (In Persian).
  71. Lancaster GI, Febbraio MA. The immunomodulating role of exercise in metabolic disease. Trends Immunol. 2014;35(6):262-9.
  72. Agha Alinejad h, Molanori Shamsi M. Exercise Induced Release of Cytokines From Skeletal Muscle: Emphasis on IL-6. Iranian Journal of Endocrinology and Metabolism. 2010;12(2):181-90. (In Persian).
  73. Irwin ML. ACSM's Guide to Exercise and Cancer Survivorship. Champaign: Human Kinetics; 2012. p. 157.
  74. Anderson EH, Shivakumar G. Effects of exercise and physical activity on anxiety. Front Psychiatry. 2013;4:27.
  75. Rahmati M, Mobasheri A, Mozafari M. Inflammatory mediators in osteoarthritis: A critical review of the state-of-the-art, current prospects, and future challenges. Bone. 2016;85:81-90.
  76. Rajendran P, Chen YF, Chen YF, Chung LC, Tamilselvi S, Shen CY, et al. The multifaceted link between inflammation and human diseases. J Cell Physiol. 2018;233(9):6458-71.
  77. Negaresh R, Motl RW, Mokhtarzade M, Dalgas U, Patel D, Shamsi MM, et al. Effects of exercise training on cytokines and adipokines in multiple Sclerosis: A systematic review. Mult Scler Relat Disord. 2018;24:91-100.
  78. Khosravi N, Hanson E, Farajivafa V, Agha-Alinejad H, Haghighat S, Molanouri Shamsi M, et al. Changes in Monocyte Populations Following Acute Aerobic Exercise in Breast Cancer Survivors. Iranian Quarterly Journal of Breast Diseases. 2018;11(1):7-16. (In Persian).
  79. Shanely RA, Nieman DC, Henson DA, Jin F, Knab AM, Sha W. Inflammation and oxidative stress are lower in physically fit and active adults. Scand J Med Sci Sports. 2013;23(2):215-23.
  80. Petersen AM, Pedersen BK. The anti-inflammatory effect of exercise. J Appl Physiol (1985). 2005;98(4):1154-62.
  81. Burd NA, West DW, Staples AW, Atherton PJ, Baker JM, Moore DR, et al. Low-load high volume resistance exercise stimulates muscle protein synthesis more than high-load low volume resistance exercise in young men. PLoS One. 2010;5(8):e12033.
  82. Bigdeli S, Dehghaniyan MH, Amani-Shalamzari S, Rajabi H, Gahreman DE. Functional training with blood occlusion influences muscle quality indices in older adults. Arch Gerontol Geriatr. 2020;90:104110.
آمار
تعداد مشاهده مقاله: 4,949
تعداد دریافت فایل اصل مقاله: 1,959
پژوهشگاه تربیت بدنی و علوم ورزشی
آمار
تعداد نشریات9
تعداد شماره‌ها334
تعداد مقالات4,054
تعداد مشاهده مقاله8,542,897
تعداد دریافت فایل اصل مقاله3,066,543