تأثیر تمرین استقامتی و عصارة متانولی گلدر بر سطوح سرمی بتاتروفین و تغییرات هیستوپاتولوژیک پانکراس در موش‌های صحرایی دیابتی‌شده با استرپتوزوتوسین

1. Lam DW, LeRoith D. The worldwide diabetes epidemic. Curr Opin Endocrinol Diabetes Obes. 2012;19: 93 6.
2. Harati H, Hadaegh F, Saadat, N, Azizi F. Population-based incidence of type 2 diabetes and its associated risk factors: Results from a six-year cohort study in Iran. BMC Public Health. 2009;16(9):1-8
3. Henquin JC, Rahier J. Pancreatic alpha cell mass in European subjects with type 2 diabetes. Diabetologia. 2011;54:1720–5.
4. Zhu JZ, Yu CH, Li YM. Betatrophin provides a new insight into diabetes treatment and lipid metabolism (Review). Biomed Report. 2014;2:447-51.
5. Lickert H. Betatrophin Fuels b cell proliferation: First step toward regenerative therapy? Cell Metab. 2013;18: 747-758.
6. Yi P, Park JS, Melton DA. Betatrophin: A hormone that controls pancreatic β cell proliferation. Cell. 2013;153:747-58.
7. Ren G, Kim JY, Smas CM. Identification of RIFL, a novel adipocyte-enriched insulin target gene with a role in lipid metabolism. Am J Physiol Endoc M. 2012; 303:334–51.
8. Cox AR, Lam CJ, Bonnyman CW, Chavez J, Rios J, Kushner JA. Angiopoietin-like protein 8 (ANGPTL8)/betatrophin overexpression does not increase beta cell proliferation in mice. Diabetologia. 2015;58:1523-31.
9. Wang H, Lai Y, Han C, Liu A, Fan C, Wang H, et al. The Effects of serum ANGPTL8/betatrophin on the risk of developing the metabolic syndrome – A prospective study. Sci Rep. 2016;6:28431. doi:10.1038/srep28431
10. Gomez-Ambrosi J, Pascual E, Catalan V, Rodriguez A, Ramirez B, Silva C, et al. Circulating betatrophin concentrations are decreased in human obesity and type 2 diabetes. J Clin Endocr Metab. 2014;99:2004-9.
11. Li E, Nakata M, Shinozaki A, Yang Y, Zhang B, Yada T. Betatrophin expression is promoted in obese hyperinsulinemic type 2 but not type 1 diabetic mice. Endocr J. 2016; 63:611-9.
12. Ghaasemi H, Tavilani H, Khodadadi I, Saidijam M, Karimi J. Circulating betatrophin levels are associated with the lipid profile in type 2 diabetes. Chonnam Med J. 2015;51: 115-9.
13. Traisaeng S, Sanguanrungsirikul S, Keelawat, S, Somboonwong S. Effect of moderate exercise training on diabetic status and pancreatic insulin content in diabetic rats. J Physiol Biomed Sci. 2014;27(1):26-31.
14. Hedayati M, Pouraoli I, Pouaboli B, Dabiri S, Javadi A. Effects of Otostegia Persica extract on serum level of glucose and morphology of pancreas in diabetic rats. Koomesh. 2014;13:201-8. (In Persian)
15. Sadeghi Z, Akaberi M, Valizadeh J. Otostegia Persica (Lamiaceae): A review on its ethnopharmacology, phytochemistry, and pharmacology. Avicenna J Phytomed. 2014;4(2):79-88.
16. Bostrom P, Wu J, Jedrychowski MP, Korde A, Ye L, Lo JC, et al. A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature. 2012;481:463-8.
17. Sharma AK, Srinivasan BP. Triple verses glimepiride plus metformin therapy on cardiovascular risk biomarkers and diabetic cardiomyopathy in insulin resistance type 2 diabetes mellitus rats. Eur J Pharm Sci. 2009;38:433-44.
18. Chang H, Park Y, Suk MH, Lee H-J, Kang H-J, Cjoi K-M, Song W. Comparison of lactate threshold, glucose, and insulin levels between OLETF and LETO rats after all-out exercise. J Sport Sci Med. 2009;8:381-7.
19. Nikooie R, Rajabi H, Gharakhanlu R, Atabi F, Omidfar K, Aveseh M, et al. Exercise-induced changes of MCTI in cardiac and skeletal muscles of diabetic rats induced by high-fat diet and STZ. J Physiol Biochem. 2013;69 (4):865-77.
20. Akbarzadeh S, Bazzi P, Daneshi A, Bargahi A. Anti-diabetic effect of Otostegia Persica extract on diabetic rats. J Med PlantS Res. 2012;6:3176-80.
21. Fenzl A, Itariu BK, Kosi L, Fritzer-Szekeres M, Kautzky-Willer A, Stulnig TM, Kiefer FW. Circulating betatrophin correlates with atherogenic lipid profiles but not with glucose and insulin levels in insulin-resistant individuals. Diabetologia. 2014;57:1204-8.
22. Gokulakrishnan G, Manokaran K, Kumar Pandy G, Amutha A, Ranjani H, Anjana RM Mohan V. Relationship of betatrophin with youth onset type 2 diabetes among Asian Indians. Diabetes Res Clin Pr. 2015;109:71-6.
23. Abu-Farha M, Abubaker J, Al-Khairi I, Cherian P, Noronha F, Hu FB. Higher plasma betatrophin/ ANGPTL8 level in type 2 diabetes subjects does not correlate with blood glucose or insulin resistance. Sci Rep. 2015;5: 2045-322.
24. Fu Z, Berhane F, Fite A, Seyoum B, Abou-Samra AB, Zhang R. Elevated circulating lipasin/betatrophin in human type 2 diabetes and obesity. Sci Rep. 2014;4:5013. doi: 10.1038/srep05013.
25. Abu-Farha M, Sriraman D, Cherian P, Alkhairi I, Elkum N, Behbehani K., et al. Circulating ANGPTL8/Betatrophin is increased in obesity and reduced after exercise training. Pos One. 2016;doi.org/10.1371.
26. Chang JK, Lyu RM, Chen XQ. Detection of C-terminal betatrophin peptides in human plasma and rodent liver. In: Nishiuchi Y, Teshima T, editors. The 4th Asia-Pacific International Peptide Symposium. Peptide Science. Suita: Phoenix Pharmaceuticals Inc; 2013. p. 243–6.
27. Tokumoto T, Hamamoto K, Fujimoto E, Yamaguchi, E, Okamura S, Honjo H, et al. Correlation of circulating betatrophin concentrations with insulin secretion capacity, evaluated by glucagon stimulation tests. Diabetic Med. 2015;32:653- 6.
28. Hedayati M, Pouraboli I, Pouraboli B. Effect of methanolic extract of Otostegia Persica on serum levels of glucose and lipids in type I diabetic male rats. Iran J Endo Metab. 2010;12:435-42. (In Persian)
29. Zhang Y, Li R, Meng Y. Irisin stimulates browning of white adipocytes through mitogen-activated protein kinase p38 MAP kinase and ERKMAP kinase signaling. Diabetes. 2014;63:514–25.
30. Traisaeng S, Sanguanrungsirikul S, Keelawat, S, Somboonwong S. Effect of moderate exercise training on diabetic status and pancreatic insulin content in diabetic rats. J Physiol Biomed Sci. 2014;27(1):26-31
31. Rawal S, Huang HH, Novikova L, Hamedi T, Smirnova IV, Stehno-Bittel L. Effect of exercise on pancreatic islet in Zucker diabetic fatty rats. J Diabetes Metab. 2013;10:1-7.
32. Gusarova V, Alexa CA, Na E, Stevis PE, Xin Y, Bonner-Weir S, et al. ANGPTL8/betatrophin does not control pancreatic beta cell expansion. Cell. 2014;159: 691–6.
33. Yi P, Park JS, Melton DA. Perspectives on the activities of ANGPTL8/betatrophin. Cell. 2014;159:467–8.